As most of us know severe asthma can be caused by hyper immune response with elevated Eosinophils and elevated IgE. This is what my doctor expected with me, but labs told a different story. 0 eosinophils and 0 basophils. All immunoglobulins in normal range, except IgE which was less than 2 indicating a deficiency. This would make since considering i'm anaphylactic to shellfish, yet with blood serum testing I showed no sign of allergy to them as they look for elevated IgE levels as a response. I also have a hard time accepting immunizations, such as having the hep b series multiple times with titters showing now evidence of immunity. Currently I am having a hard time finding any information or research about this particular deficiency. Anyone here have any experience with this or advice? I don't meet with my doctor for another month but was advised to get a pneumonia vaccine asap and just trying to educate myself on this so I can narrow down some of the questions I have when we do meet.