Lidocaine to help treat asthma??

So, my dad, a retired anesthesiologist, asked me today if I had heard of using lidocaine to help treat asthma.  He explained the pharmacology to me but while it made sense at the time, I just don't know it well enough to try to explain it.  Many, many years ago he was the first to use it extensively in our area for anesthesia and other medical circumstances although not the first to use it in the U.S.  One of the hospitals where he was a visiting professor was the Mayo Clinic and he gave lidocaine lectures there.  Lidocaine has been used for many decades.

Basically if I understood it correctly, he was wondering if lidocaine would somehow interrupt whatever was triggering the asthma.  I don't remember how he said it or what else he said.

So I looked up any connection between lidocaine and asthma and came up with these research articles.

In the Introduction of the above article –

In recent years, lidocaine has been used to treat asthma. A report showed that both venoclysis and nebulized inhalation of lidocaine can attenuate bronchial hypersensitivity (BHS) in asthma patients.[] Evidence indicated that lidocaine can promote the apoptosis of eosinophils, which is normally delayed by IL-5,[] and that it has a good effect on serious steroid resistant asthma (SRA).[] The present study was undertaken to determine the effect of nebulized inhalation of lidocaine on various types of asthma after an acute onset.

Interesting how it says "lidocaine can promote the apoptosis of eosinophils" where apoptosis is " genetically directed process of cell self-destruction that is marked by the fragmentation of nuclear DNA, is activated either by the presence of a stimulus or removal of a suppressing agent or stimulus . . . " according to the Merriam-Webster online dictionary. 

Has anyone been treated with lidocaine for asthma?  Have you heard of any other studies with lidocaine?  Thoughts??



Comments 2

  • Amber Says Shine

    This is really interesting. I haven't been treated with lidocaine, but I love research. So I'll be reading more and looking forward to others' input. 

  • K8sMom2002

    I haven't heard of this … very interesting. I know that in both past surgeries for me and DD, anesthesiologists have been marvelous at managing both of our asthma conditions during surgery.