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Dupixent and Nucala

Hi. I haven’t posted for a while. I have been on Nucala for 1 year and three months. It has helped me but not completely. I have been having more asthma problems since I have increased my activities outside the house –

  1. spending time outside
  2. going on vacation which involved daily outdoor activities, restaurants, hotels etc.
  3. just trying to do activities like a “regular” person

Once I started having more asthma and allergy problems, I realized I had gotten in a pattern of going to work and coming home.

My vacation resulted in daily Prednisone and Albuterol inhaler/nebulizer treatments. Prior to starting Nucala, I was on Xoliar for several years and then it stopped working. My pulmonologist is now thinking about switching me to Dupixent.

I would like to hear from anyone who is taking Dupixent.

Has it helped you?

How soon after you started Dupixent did you show improvement?

What side effects have you had?

Have you had any difficulty giving yourself the injection?

How often do you give yourself the injection?

Thanks for any information you can give me.

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Comments 4

  • LK

    Hi MMKB!

    Yes, I am taking Dupixent.  I was on Xolair for almost a year and did not notice much improvement.

    I started Dupixent the end of January this year and noticed a big improvement withing about 3 days.  I wasn't expecting to see any improvement for several weeks or more but all of a sudden I felt like I could take a very deep breath.  Deeper than I had been able to take for years. 

    Has it helped you?   Yes, it has.  I still have severe asthma but on the good days my breathing is so much better.  Even on the hard to breathe days, it is much better than it was on the good days before Dupixent.

    How soon after you started Dupixent did you show improvement?  For me, it was about 3 days later but I do now know if that is a common outcome or not.

    What side effects have you had?   The only side effect has been a local injection site reaction -  a rash.  The rash would appear about 10 – 20 days after the injection.  I keep a record of where I give the injections and any reactions.  I was giving the first injections on my stomach and did not use Benadryl the first time.  My doctor suggested taking Benadryl before the injection and I did and it helped but still got a rash.  Then he had me increase the Benadryl to 50mg before the injection and another dose in the evening and that has taken care of the rash.  Have not had any rash at all since doing that.  Also have been giving my injections in my thighs.

    Have you had any difficulty giving yourself the injection?  I admit it takes a little to get used to doing it.  I have given horses intramuscular injections for years so am slightly familiar with injections but not giving them to myself.  The Dupixent My Way program will have a field nurse come out and coach you through the process.  You have to do the injection but she has a training syringe so you get to practice as much as you need to do.  The phone RNs are very helpful, as well, and are happy to answer any questions.

    There is also a video on the Dupixent website showing how to do the injection.

    It does get easier each time you do it.  I believe that having it done at a doctor's office is also an option if you are not able to give the injection to yourself.  

    How often do you give yourself the injection?  Mine is every 14 days.  The first injection, loading dose, is two injections the first day, then one injection every 14 days.  I am on the 300 ml dose.

    Have you looked around the Dupixent website?  It has lots of good information in addition to what you talk about with your doctor.

    Hope this is helpful for you!

    Please let us know how you are doing and if I can answer any more questions, please let me know.

  • MMKB

    Melissa and Lisa,

    Thanks for your messages! The information was very helpful!

    Lisa – Was is hard for you to get our insurance company to cover Dupixent? Did you have to be off the Xoliar for a length of time before you could start the Dupixent? Do you have severe allergies in addition to your severe asthma? If you have severe allergies, has the Dupixent helped your allergies too?

  • LK
    MMKB posted:

    Melissa and Lisa,

    Thanks for your messages! The information was very helpful!

    Lisa – Was is hard for you to get our insurance company to cover Dupixent? Did you have to be off the Xoliar for a length of time before you could start the Dupixent? Do you have severe allergies in addition to your severe asthma? If you have severe allergies, has the Dupixent helped your allergies too?

    MMKB,  My pulmonologists office handled every bit of the approval process for both the Xolair and the Dupixent, so I am not sure what all they had to do.  I did not have to be off the Xolair for any length of time before starting the Dupixent.  I specifically asked my pulmo about that.  My last Xolair injections were the first part of January and my first Dupixent was the end of January. 

    I have kept a record of my FEV values before and after using either my rescue inhaler or albuterol in my nebulizer and showed that to my pulmo.  It showed that my FEV numbers always improved after the bronchodilator.   

    Dust mites are the only thing that I showed any allergies to but I only had blood tests and no skin tests for allergies.  I had to ask my pulmo about allergies and by then I was already on Xolair so any skin allergy testing would be moot, according to my allergist.  (Didn't see him until after I was on the Xolair and he said I would have to be off it for 4-6 months before I could do any allergy testing.)