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Blood Pressure ACE Inhibitor Affecting Asthma?

Recently been prescribed an ACE inhibitor (perindopril) for elevated blood pressure. Within two or three days I have become quite wheezy and have developed an annoying cough. Literature indicates this type of bp prescription can have this sort of side effect.

Has anyone else had a similar experience?

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  • Kathy P

    I remember my hubby developed a weird dry cough from on bp med he was put on. I don't recall which med it was though.Have you talked to the doc about trying a different med?

  • K8sMom2002

    That's got to be more than a little annoying and worrisome … glad you're seeing your doctor on Monday. What's helping the wheeze and the cough in the meantime?

  • Kathy P

    Did you call to see if you should continue taking it through Monday?

    I know the ENT I saw today carefully went over every med I was taking to see if any could be causing my cough/voice issues. Med side effects and interactions can really be tricky to track down sometimes.

  • jujutsumaster

    No I should have done that but I think that I'll give the med a miss tomorow and Sunday. Does seem to be getting worse. Just had a couple puffs of my inhaler as I'm feeling a bit short of breath etc.

    Been doing some more reading and it seems that ACE inhibitors and Beta Blockers can cause problems for some athsmatics.

    Should have gone teaching/training this evening but giving it a miss. Don't feel up to it.

    I'm no medic so can't say for shure that this is the perindopril but it seems too much of a coincidence to me.

  • Kathy P

    That's not good if it seems to be getting worse and that you have to miss your usual activities.

    Glad you are seeing the doc on Monday.

  • K8sMom2002

    Hope you get some answers and a good plan going forward on Monday, and I'm sorry you're not feeling up to teaching tonight. Maybe rest will help.

  • Shea

    I did have that problem with ACE inhibitors and Beta Blockers on worsening my asthma. One medication landed me in the ER. ANother just made my wheezing and asthma worse, and cause alot of fatigue because I already have a kinda low blood pressure (I was not taking these medication to reduce blood pressure, but to improve ejection fraction). My heart doctor tried to reduce the dose of meds and change up the medications, but I finally decided that worsening asthma and fatigue outweighed the possibility that these medications could improve my ejection fraction over time(which was my reason for taking those medications after an allergic disease called Churg-Strauss Syndrome was implicated in causing me a myocardial infarction due to eosinophils in my blood causing pressure on the heart and causing the attack). I suggest discussing the medications with both your heart doctor and your asthma-lung doctor, because then you have two specialists' opinions to help you weigh out the pros and cons, one alone can have too narrow of focus sometimes.

  • jujutsumaster

    Thank you for the info SHEA.

    Fortunately I don't have any heart condition at present, just slightly elevated bp so don't have a heart specialist.

    Here in the UK my asthma is being managed by my family doctor practice and I'm convinced that my asthma deterioration in the last few days is due to the ACE. Too much coincidence to be otherwise.

    I'm going back to see the doc Monday morning so I'll post on the outcome.

  • Mandy

    Good you are seeing your Doctor on Monday and taking it easy this weekend. Heart and asthma issues are exhausting.Take care!

  • jujutsumaster

    Feeĺing a little fatigued but otherwise ok. Lungs felt congested first thing but improved a lot now.

    Thanks for your concern.

  • Kathy P

    Glad you are feeling ok. I don't think it's unusual for "just high bp" to be managed by a family/primary doc. My dh has been on bp meds for years and never had a specialist. 

  • K8sMom2002

    Glad for the improvement! And yes, lots of times the simple uncomplicated stuff can be handled by my primary care doc — I rather prefer it, because it means that things can be better coordinated. Sometimes it can get tricky with lots of specialists who have to coordinate care plans between them. 

    But for the complex and the out of the normal, that's when I go to a specialist.  Let us know what the doc says!

  • Shea

    Nigel, in your case a primary care doctor sounds appropriate–primary care doctors often have a good sense of balance, feeling responsible for the whole patient, whereas specialists can sometimes feel only responsible for their area. My cardiologist did say that Losartan and Metoprolol were better for those with asthma, so you can always ask your doctor about those medications. Good luck at your appointment!

  • jujutsumaster

    Saw my doc this morning. He agreed that Perindopril was likely to affect my asthma (apparently it's about 1 in 25 chance).

    Now prescribed Candesartan cilexetil which is not an ACE inhibitor.

    Doc says it may take a week or two to get back to normal.

  • Kathy P

    Hope the new med works for your bp and does not affect your asthma. Areyou still feeling some asthma issues from the ACE inhibitor?

  • K8sMom2002

    Bummer on the 1 in 25 chance, but here's hoping that the change will help and will also help your BP. Fingers crossed!

  • K8sMom2002

    @jujutsumaster, hoping things are continuing to improve for you — have you checked your BP to be sure the meds are working well to solve that problem as well?

  • jujutsumaster

    Yes thank you, the cough has eased lot over the last few days and breathing back to normal.

    The blood pressure meds seem to work better than Perindopril. Checked pressure early this morning and read an impressive 123/79. 

  • K8sMom2002

    That's a win-win! When did you find out your blood pressure was high? As active as you are, it tells me I really need to do more exercise.

  • jujutsumaster

    Before I took early retirement /voluntary redundancy five yrs ago, I had a fairly high pressure job and was diagnosed with high no so was out on minimum dose ACE inhibitor.

    After finishing work my bp dropped back to normal for age and doc took me off it. 

    I check my bp about once a week and it has climbed around 14o+/90 over a few months so back to doc for a check up.

    I have a great doc – he's always keen to review meds and adjust where possible.

    As for exercise, I really haven't done enough recently so need to get more walks etc  and lose 7-14 pounds.

  • jujutsumaster

    Oops! looks like auto spell checker kicked in first para. Should have read ….. with high bp so was put on …?

  • K8sMom2002

    No problem … I figured it out. I actually read it as high numbers with "No" as the abbreviation for number.

    You and me both, Nigel, on the exercise and weight loss!

  • Jen

    @jujutsumaster Nigel – Are things still going well with the new blood pressure meds?

  • jujutsumaster

    Ok thanks. But just makes me determined to crack on with the exercise and weight loss to see if I can dispense with the med.

  • K8sMom2002

    Nigel, I think that's a worthy goal indeed! What sorts of things are you planning to do increase your exercise? I need some inspiration! I'm turning into such a couch potato that I may sprout leaves and blossoms!

  • jujutsumaster

    It's not easy. I am reasonably active but I think my metabolism has slowed with age.

    I'm walkng a lot more, leaving the car at home where I can and taking up my gym membership again. Start slow but gradually increasing walking pace and incline on the treadmill. Also doing resistance work.

    I can't run because in 2011 I had a torn meniscus cartilage which was operated on but if I run can play up. So better safe than sorry.

    Cutting down on food portions and resisting temptation to eat later in the evening.

    Sounds boring to some I'm sure but there's no easy way, well not for me!

    The good thing is that fitness improves fairly quickly and so does the feeling of wellbeing.

  • K8sMom2002

    Oh, it's SO much more fun in the short run to sit on the couch or snack on tasty treats — but you're right. That feeling of well-being is worth all the short-term sacrifice. 

    I think I shall try to include more walking and more bodyweight exercises. I need to see my doctor about getting cleared for exercise because of other health issues that have cropped up, but once I get the all clear, I'll start back on my exercise bike — I haven't been using it since the late summer when I started having some episodes of tachycardia. I'd thought it was going to be something that would resolve on its own, but it hasn't. So off to the doctor I go to get my all-clear to exercise! (Soon, I promise!)

  • jujutsumaster

    Good call. I spoke to my doc about getting back to the gym when we discussed my bp. He gave me the all clear but did say to take it gradually.

  • Jen

    One thing is that once you get in the regular habit of exercise, you actually start to crave it. Your body and mind feel it when you miss a regular workout.  

  • Kathy P

    Sometimes high bp is genetic. My dh has not changed weight in 25 yrs, exercises regularly (road cycling) and still has high bp and needs meds. But his dad and their family all had high bp issues.

  • K8sMom2002

    @jujutsumaster, is the change in meds still going well? 

    Jen, I'm hoping that one day I'll get addicted to exercise, but so far it hasn't happened.

  • K8sMom2002

    @jujutsumaster, checking in to see if your change in meds is working — both with the BP and with the asthma …

  • jujutsumaster

    A mixed bag. Blood pressure excellent and the ACE Inhibitor throat cough has gone.

    However breathing has not been so good for about 10 days with a chesty cough and asthmatic tightness and feeling a bit short of breath. Had to use Salbutamol three or four times a day.

    Should explain that several family members have had a stubborn viral cough lasting weeks so may have caught this myself.

    Doc wanted to see me a month after starting the new bp med and to review blood tests he arranged. Saw him on Friday and he says that my breathing is most unlikely to be caused by the bp med. He says I have signs of a slight upper respitory infection but doesn't want to prescribe antibiotics unless things get worse.

    Today has been much better so maybe on the mend.

    Bloods results were all normal and very pleasing that cholesterol level is good so no statin required.

     

  • K8sMom2002

    Bummer on the cough and the tight chest — I've had issues with upper respiratory infections that grab hold of my lungs, and it is a pain to get over them.

    When you say your family members' infections have lasted "weeks," what do you mean? A couple of weeks? A month?

    The reason I ask is that my DD's doctors say that they like to hold antibiotics for a couple of weeks to see if it's viral. If it's longer than 2 weeks, they will then add an antibiotic. She also has a standby prescription for prednisone in case it gets in her lungs and the inhaler isn't helping. 

  • jujutsumaster

    About four to five weeks. My Son's cough has cleared now but neither he or my wife have been to see a doc. Convinced it'll clear up and they're probably correct. Then neither of them have asthma.

    For me, I believe in letting the immune system do its job and it can take time but my doc told me to go straight back if things get worse.

    I've had personal experience of antibiotics not working as originally intended due to bug resistance.

    In 2005/2006 I acquired resistant Psuedomonas with bacteremia after being catheterized. They tried seven different oral antibiotics before the lab finally worked it out (I should have sued). Then I was given intravenous infusions of Gentamicin on the chemo ward under close supervision. I was really ill at the time.

    Thankfully that did the trick, although my Urology specialist told me that  "I was drinking in the last chance saloon". That guy never gave up on me and saved my life.

  • Jen

    Nigel – Glad to hear the meds are working for you.  I hope that you continue to improve from whatever you have going on.  I can certainly understand your reluctance with antibiotics.  

  • K8sMom2002

    Ditto on the antibiotics, Nigel — beyond resistance and "super bugs," my doctors and my DD's doctors were concerned with our "gut" health and the other complications of antibiotics.

    They're marvelous when they work, but I'm like you — if the body can do it on its own, that's even better. 

  • K8sMom2002

    Nigel, how is the cough and chest tightness doing? I hope you (and your family!) are on the mend!

  • jujutsumaster

    Sorry not got back earlier. We had a family attack of Norovirus, started by one of our grandchildren. All better now.

    Still a bit tight chested early morning due I think to a bit of an infection otherwise OK. Not getting any worse but I'll get back to the doc if it's not cleared in the next day or so.

  • K8sMom2002

    Oh, my goodness! Nothing like a good ol' round of Norovirus to make you thankful you're all better! Glad you checked in, but I'm sorry to hear that your chest is still tight. Keep us posted!

  • Kathy P

    Wish kids wouldn't share those germs! Glad you are feeling better and the chest tightness goes away.

  • Mandy

    Eeekkk on the germ sharing. My little one's love to share as well Glad you are on the mend.

  • K8sMom2002

    Nigel, how are things with the norovirus and the breathing issues? Are your BP meds still working well?